Protein requirements on GLP-1: systematic review of RDA vs optimal intake — what worked for you?

HPLC_Greg said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Adding the numbers, since they settle part of this. A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator. Three questions, and they resolve most disagreements in these threads.

TrialTracker_MD said:

I will push back on the powder-first advice.

Adding the part of the answer the thread has not reached. Read four things before the headline number. The population, because trial populations are selected and supported in ways that real cohorts are not. The comparator, because "better than placebo" and "better than the current standard" are different claims and get reported identically. The primary endpoint as pre-registered, because a secondary endpoint promoted after the fact is a hypothesis rather than a finding. And the completion rate, because a large effect in the half of participants who finished is a different result from a large effect in everybody enrolled.

One thing that is still open after BenResearch_OR’s answer:

How people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness?

Closing the loop on my own question.

Reporting back — setting the target on reference weight rather than current weight turned an impossible number into a boring one.