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ForumsNutrition & SupplementationVitamin D optimization on GLP-1 — testing and dosing guide

Vitamin D optimization on GLP-1 — testing and dosing guide

Dr.Martinez Tue, May 12, 2026 at 7:12 AM 8 replies 422 viewsPage 1 of 2
Dr.Martinez
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May 12, 2026 at 7:12 AM#1

A reference post rather than a discussion. Corrections are the point; I would rather this be right than mine. It is about micronutrient cover, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium. Two of those are worth testing rather than guessing because the tests are cheap and the symptoms overlap with everything else — ferritin and B12. The rest a decent multivitamin covers, and there is no benefit in megadosing any of them.

The condition it depends on

The caveat that iron should be tested before supplementing, not after. Supplementing iron into normal stores is unpleasant at best and harmful in haemochromatosis.

The practical version

Cheap and worth having: ferritin, B12, vitamin D. Everything else on the deficiency list is adequately covered by a standard multivitamin at ordinary doses.

What I am not sure about

So the question, as narrowly as I can put it: which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind. Numbers rather than impressions, if you have them.

— Dr.Martinez · corrections welcome and will be edited into this post with credit
4 24AttorneyGrant, DebRD_ATL, KristenIndy and 1 other
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PharmD_Rodriguez
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May 12, 2026 at 8:37 AM#2
Dr.Martinez said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Iron studies on micronutrients — important especially for women:

MarkerBaselineMonth 6After Supplementation
Ferritin712456
Iron1016184
TIBC336406336
Transferrin Sat34%16%27%

My ferritin cratered at month 6 from reduced dietary intake. Iron bisglycinate 36mg with vitamin C brought it back up. Don't wait for anemia symptoms — test proactively.

Last edited: May 12, 2026 at 1:37 PM
3 23TinaHashiRN, robert_kc, dan_philly
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Dr.CardioMD
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May 12, 2026 at 10:02 AM#3
Dr.Martinez said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 89 → 98 fL. This flagged potential B12 or folate deficiency.

Sure enough, B12 had dropped from 620 to 340 pg/mL. Started B12 injections monthly and MCV normalized within 2 months. GLP-1 agonists can impair B12 absorption — this is a real clinical concern that deserves routine monitoring.

2 22tony_orlando, Dr.NephBHM_UK
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Dr.PulmRoch
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May 12, 2026 at 11:27 AM#4
Dr.CardioMD said:
Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 89 → 98 fL.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 72 to 29. Supplementing.
  • Vitamin D: Was already low (19 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

1 21DebRD_ATL
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NauseaFreeNow
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May 12, 2026 at 7:42 PM#5
PharmD_Rodriguez said:
Iron studies on micronutrients — important especially for women: Marker Baseline Month 6 After Supplementation Ferritin 71 24 56 Iron 101 61 84 TIBC…

Mine went the same way, slower.

Last edited: May 12, 2026 at 11:42 PM
50 20cory_ATX, lori_vegas, Dr.PulmRoch and 47 others
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