I promised I'd come back and share my labs after 6 months, so here we go. For context: 45M, started at 267lbs, now 224lbs (43lbs lost). T2D diagnosed 2022, also had NAFLD and hypertension. Currently on sema 1.7mg.
| Marker | Baseline (Sept 2025) | 6 Months (Jun 2026) | Reference Range | Change |
|---|---|---|---|---|
| A1C | 7.8% | 5.6% | <5.7% | ↓ 2.2 pts |
| Fasting Glucose | 168 mg/dL | 94 mg/dL | 70-100 | ↓ 44% |
| Fasting Insulin | 28.4 μIU/mL | 11.2 μIU/mL | 2.6-24.9 | ↓ 61% |
| Total Cholesterol | 242 mg/dL | 189 mg/dL | <200 | ↓ 22% |
| LDL | 158 mg/dL | 112 mg/dL | <100 optimal | ↓ 29% |
| HDL | 38 mg/dL | 52 mg/dL | >40 | ↑ 37% |
| Triglycerides | 312 mg/dL | 138 mg/dL | <150 | ↓ 56% |
| ALT | 62 U/L | 28 U/L | 7-56 | ↓ 55% |
| AST | 48 U/L | 24 U/L | 10-40 | ↓ 50% |
| CRP (hs) | 6.8 mg/L | 1.4 mg/L | <3.0 | ↓ 79% |
| Blood Pressure | 148/92 | 128/82 | <130/80 | ↓ improved |
| Creatinine | 1.1 mg/dL | 1.0 mg/dL | 0.7-1.3 | → stable |
My doctor was genuinely emotional at this appointment lol. He said in 20 years of practice he's never seen metabolic markers improve this dramatically in 6 months without bariatric surgery.
The NAFLD is essentially resolved based on my liver enzymes and a follow-up ultrasound. He's talking about taking me off my blood pressure medication at our next visit.
I'm still on metformin but we're discussing tapering that too since my A1C is now in the non-diabetic range. Lifestyle changes alongside the medication: walking 30-45 min daily, high protein diet (~130g/day), no alcohol.
Bro. THAT TRIGLYCERIDE DROP. 312 → 138?! That's insane. And your hs-CRP going from 6.8 to 1.4 is massive — that's a huge reduction in systemic inflammation.
These are the results that make me rage when people call GLP-1 meds "vanity drugs." This isn't about looking good in a swimsuit, this is about not dying of a heart attack at 55.
Incredible work man. 👏
Excellent results. A few clinical notes for context:
The triglyceride reduction of 56% is above what the STEP trials typically showed (~17-20% average), suggesting you may have been particularly responsive to the metabolic effects, or your dietary changes (especially cutting alcohol) contributed significantly. Alcohol is a major driver of elevated triglycerides.
The liver enzyme normalization is consistent with emerging data on semaglutide for NAFLD/NASH. There are actually ongoing trials (the ESSENCE trial) specifically studying semaglutide for NASH resolution.[1]
Regarding metformin discontinuation — I'd recommend discussing with your doctor keeping it even if A1C is normal. There's growing evidence that metformin has independent cardioprotective and potentially anti-aging effects beyond glucose control. Plus, the combination may help prevent weight regain.
One lab I'd recommend adding at your next visit: a fasting lipid panel with LDL-P (particle number) and Lp(a). Standard LDL-C doesn't tell the whole story, especially with rapid weight loss.
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Browse GL BiochemSaving this post. I'm 3 months in and my labs aren't as dramatic but trending in the same direction. Your CRP drop gives me hope — my inflammation markers are still high.
This is goals. I'm at month 2 and honestly getting impatient seeing other people's results. But I know I need to trust the process.
Can I ask — did you have any side effects that affected your labs? I've heard some people get elevated lipase/amylase on sema?