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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationCollagen peptides for GLP-1 skin elasticity — any evidence?

Collagen peptides for GLP-1 skin elasticity — any evidence?

Dr.Martinez Fri, Jun 5, 2026 at 7:31 PM 3 replies 149 viewsPage 1 of 1
Dr.Martinez
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Jun 5, 2026 at 7:31 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

The narrow version of the question is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be.

Numbers rather than impressions, if you have them.

4 24AttorneyGrant, DebRD_ATL, KristenIndy and 1 other
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PharmacoVig_BOS
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Jun 5, 2026 at 7:36 PM#2

This one has a reasonably settled answer, so here it is. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

3 23Dr.GutHealth, amsterdam_pete, LondonLisa
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PharmD_Rodriguez
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Jun 5, 2026 at 7:41 PM#3
PharmacoVig_BOS said:
Distribution matters less than total but it is not nothing.

Agreed on the target, with the caveat that reference weight and current weight are different numbers. Using current weight at the start of a large loss produces a target that is both unachievable and unnecessary.

2 22robert_kc, dan_philly
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NurseAsh_DET
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Jun 5, 2026 at 7:46 PM#4
Dr.Martinez said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

Can confirm the pattern Dr.Martinez describes. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

Last edited: Jun 6, 2026 at 1:46 AM
1 21labquiet_amy
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NurseLeah_Nash
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Jun 5, 2026 at 8:13 PM#5

From the other side of the consultation, briefly.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass255 lbs215 lbs202 lbs
Fat mass105 lbs75 lbs52 lbs
Lean mass158 lbs154 lbs149 lbs
Body fat %40%34%21%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

50 20Dr.NateNeph, PharmD_Rodriguez, julia.endo and 47 others
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